製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to WBSCR22
  • アプリケーション
    適用あり: IHC-P, ICC/IF, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to a sequence within amino acids 1-233 of Human WBSCR22 (NP_059998).

  • ポジティブ・コントロール
    • 293T cell lysate transfected with WBSCR22; CA922 xenograft tissue.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab97911 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/250. The staining pattern is dependent on the antibody titer and nature of the biology. Proliferating tumor cells might be positive for nuclear staining while the differentiated cells show no nuclear staining. Antibody titer and antigen retrieval time should be adjusted.
ICC/IF Use at an assay dependent concentration. PubMed: 24086612
WB 1/500 - 1/3000. Predicted molecular weight: 32 kDa.

ターゲット情報

  • 機能
    Methyltransferase that may act on DNA.
  • 組織特異性
    Strongly expressed in heart, skeletal muscle and kidney. Also expressed in spleen, liver, lung and testis.
  • 関連疾患
    Note=WBSCR22 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR22 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 配列類似性
    Belongs to the methyltransferase superfamily.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HASJ4442 antibody
    • HUSSY 3 antibody
    • HUSSY3 antibody
    • PP3381 antibody
    • Uncharacterized methyltransferase WBSCR22 antibody
    • WBMT antibody
    • WBS22_HUMAN antibody
    • WBSCR22 antibody
    • Williams Beuren candidate region putative methyltransferase antibody
    • Williams Beuren syndrome chromosome region 22 protein antibody
    • Williams-Beuren syndrome chromosomal region 22 protein antibody
    see all

画像

  • All lanes : Anti-WBSCR22 antibody (ab97911) at 1/500 dilution

    Lane 1 : Non-transfected lysate
    Lane 2 : 293T cell lysate transfected with WBSCR22


    Predicted band size : 32 kDa
  • ab97911 at 1/100 dilution staining WBSCR22 in CA922 xenograft by Immunohistochemistry, Paraffin-embedded tissue.

参考文献

This product has been referenced in:
  • Zorbas C  et al. The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Mol Biol Cell 26:2080-95 (2015). WB . Read more (PubMed: 25851604) »
  • Ounap K  et al. The Human WBSCR22 Protein Is Involved in the Biogenesis of the 40S Ribosomal Subunits in Mammalian Cells. PLoS One 8:e75686 (2013). ICC/IF ; Human . Read more (PubMed: 24086612) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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