製品の概要

  • 製品名
    WAY-100635 maleate
  • 製品の詳細
    Potent, selective, silent 5-HT1A receptor antagonist
  • 生理活性の詳細
    Potent, selective, silent 5-HT1A receptor antagonist (IC50 = 1.35 nM).
    Displays >100-fold selectivity for 5-HT1Arelative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels. Binds selectively to rodent brain 5-HT1A receptors in vivo (iv admin). Unlike WAY100135, WAY100635 displays no partial agonist activity in the ventral hippocampus of rats.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Mensonides-Harsema MM  et al. Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635. J Med Chem 43:432-9 (2000). Read more (PubMed: 10669570) »
  • Fletcher A  et al. Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Behav Brain Res 73:337-53 (1996). Read more (PubMed: 8788530) »
  • Assié MB & Koek W Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY100635, has partial agonist properties. Eur J Pharmacol 304:15-21 (1996). Read more (PubMed: 8813579) »

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