製品の概要

  • 製品名Anti-WAVE 1 antibody
    WAVE 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to WAVE 1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Cow
  • 免疫原

    Synthetic peptide:

    AVEYSDSEDDSEFDEVDWLE

    conjugated to KLH, corresponding to C terminal amino acids 540-559 of Human WAVE 1

  • ポジティブ・コントロール
    • Rat and mouse brain cytosolic fractions.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab50356 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 0.2 - 0.4 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 62 kDa). Staining of the WAVE band is specifically
    inhibited with the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
    • 組織特異性Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
    • 配列類似性Belongs to the SCAR/WAVE family.
      Contains 1 WH2 domain.
    • ドメインBinds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
    • 細胞内局在Cytoplasm > cytoskeleton. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
    • Information by UniProt
    • 参照データベース
    • 別名
      • WASP family, verprolin homology domain-containing protein 1 antibody
      • WASP family member 1 antibody
      • FLJ31482 antibody
      • homology of dictyostelium scar 1 antibody
      • KIAA0269 antibody
      • Protein WAVE-1 antibody
      • Protein WAVE1 antibody
      • scar, Dictyostelium, homology of, 1 antibody
      • SCAR1 antibody
      • Similar to a plant extensin like protein antibody
      • Verprolin homology domain containing protein 1 antibody
      • Verprolin homology domain-containing protein 1 antibody
      • WAS protein family, member 1 antibody
      • Wasf1 antibody
      • WASF1_HUMAN antibody
      • WASL antibody
      • WASP family 1 antibody
      • WASP family protein member 1 antibody
      • WASP family, verprolin homology domain-containing protein antibody
      • WAVE antibody
      • WAVE1 antibody
      • Wiskott Aldrich syndrome protein family member 1 antibody
      • Wiskott-Aldrich syndrome protein family member 1 antibody
      see all

    Anti-WAVE 1 antibody 画像

    • All lanes : Anti-WAVE 1 antibody (ab50356) at 1/4000 dilution

      Lane 1 : Mouse brain (cytosolic fraction S1)
      Lane 2 : : Rat brain (cytosolic fraction S1)
      Lane 3 : : Rat brain (cytosolic fraction S1) with immunizing peptide at 20 µg/ml

      Secondary
      Goat Anti-Rabbit IgG, Peroxidase conjugate
      Developed using the ECL technique

      Predicted band size : 62 kDa
      Observed band size : 75 kDa (why is the actual band size different from the predicted?)

    Anti-WAVE 1 antibody (ab50356) 使用論文

    This product has been referenced in:
    • Payne LJ  et al. p53 Down Regulates PDGF-Induced Formation of Circular Dorsal Ruffles in Rat Aortic Smooth Muscle Cells. PLoS One 9:e108257 (2014). WB . Read more (PubMed: 25247424) »
    • Nascimento DS  et al. Satellite Glial Cells Surrounding Primary Afferent Neurons Are Activated and Proliferate during Monoarthritis in Rats: Is There a Role for ATF3? PLoS One 9:e108152 (2014). WB . Read more (PubMed: 25247596) »

    See all 3 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab50356.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"