Immunohistochemical analysis of rat dorsal root ganglia and spinal cord indicates high level of specificity for this antiserum.
Cross reactivity: This antibody is known to react with rat. Other species have not been tested yet.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Western Blot: Not tested.
Immunoblot: Not tested.
1 site ELISA: Not tested.
Biological Inhibition: Not tested.
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. Contains 6 ANK repeats.
N-glycosylated. Phosphorylated by PKA.
Cell membrane. Cytoplasm. Melanosome. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.