製品の概要

  • 製品名Anti-VPS36 antibody
    VPS36 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to VPS36
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 91-140 (SNKEPGPFQS SKNSYIRLSF KEHGQIEFYR RLSEEMTQRR WETVPVSQSL) of Mouse VPS36 (NP_081614).

  • ポジティブ・コントロール
    • Mouse liver lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab125715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
  • 配列類似性Belongs to the VPS36 family.
    Contains 1 GLUE C-terminal domain.
    Contains 1 GLUE N-terminal domain.
  • ドメインThe GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides.
  • 細胞内局在Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C13orf9 antibody
    • CGI 145 antibody
    • EAP45 antibody
    • ELL associated protein of 45 kDa antibody
    • ELL-associated protein of 45 kDa antibody
    • ESCRT-II complex subunit VPS36 antibody
    • Vacuolar protein sorting associated protein 36 antibody
    • Vacuolar protein-sorting-associated protein 36 antibody
    • Vps36 antibody
    • VPS36_HUMAN antibody
    see all

Anti-VPS36 antibody 画像

  • Anti-VPS36 antibody (ab125715) at 1 µg/ml + Mouse liver lysate at 10 µg

    Predicted band size : 44 kDa

Anti-VPS36 antibody (ab125715) 使用論文

ab125715 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"