製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to VPS36
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Zebrafish
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 120-278 of Human VPS36 (AAH37279).

  • ポジティブ・コントロール
    • NT2D1 whole cell lysate; IMR32, U87-MG, MCF-7 cell lysates

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab101379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 44 kDa.

ターゲット情報

  • 機能
    Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
  • 配列類似性
    Belongs to the VPS36 family.
    Contains 1 GLUE C-terminal domain.
    Contains 1 GLUE N-terminal domain.
  • ドメイン
    The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides.
  • 細胞内局在
    Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C13orf9 antibody
    • CGI 145 antibody
    • EAP45 antibody
    • ELL associated protein of 45 kDa antibody
    • ELL-associated protein of 45 kDa antibody
    • ESCRT-II complex subunit VPS36 antibody
    • Vacuolar protein sorting associated protein 36 antibody
    • Vacuolar protein-sorting-associated protein 36 antibody
    • Vps36 antibody
    • VPS36_HUMAN antibody
    see all

画像

  • Anti-VPS36 antibody (ab101379) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

    Predicted band size : 44 kDa

プロトコール

参考文献

ab101379 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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