Anti-Von Willebrand Factor 抗体 [F8/86] (ab778)
Key features and details
- Mouse monoclonal [F8/86] to Von Willebrand Factor
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Von Willebrand Factor antibody [F8/86]
Von Willebrand Factor 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [F8/86] to Von Willebrand Factor -
由来種
Mouse -
アプリケーション
適用あり: IHC-P, IHC-Frmore details -
種交差性
交差種: Human
交差が予測される動物種: Rabbit -
免疫原
Full length native protein (purified) corresponding to Human Von Willebrand Factor. Von Willebrand Factor isolated from human plasma.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.3
Preservative: 0.05% Sodium azide
Constituents: Tissue culture supernatant, 1% BSA -
Concentration information loading...
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精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
F8/86 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab778の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (3) |
1/25 - 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
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IHC-Fr |
Use at an assay dependent concentration.
ABC method. We suggest an incubation period of 60 minutes at room temperature. |
特記事項 |
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IHC-P
1/25 - 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. |
IHC-Fr
Use at an assay dependent concentration. ABC method. We suggest an incubation period of 60 minutes at room temperature. |
ターゲット情報
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機能
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. -
組織特異性
Plasma. -
関連疾患
Defects in VWF are the cause of von Willebrand disease (VWD) [MIM:277480]. VWD defines a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. Type I von Willebrand disease is the most common form and is characterized by partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor; type II is associated with a qualitative deficiency and functional anomalies of the Willebrand factor; type III is the most severe form and is characterized by total or near-total absence of Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. -
配列類似性
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 4 TIL (trypsin inhibitory-like) domains.
Contains 3 VWFA domains.
Contains 3 VWFC domains.
Contains 4 VWFD domains. -
ドメイン
The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. -
翻訳後修飾
All cysteine residues are involved in intrachain or interchain disulfide bonds.
N- and O-glycosylated. -
細胞内局在
Secreted. Secreted > extracellular space > extracellular matrix. Localized to storage granules. - Information by UniProt
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参照データベース
- Entrez Gene: 7450 Human
- Omim: 613160 Human
- SwissProt: P04275 Human
- Unigene: 440848 Human
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別名
- Coagulation factor VIII antibody
- Coagulation factor VIII VWF antibody
- F8VWF antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (14)
ab778 は 14 報の論文で使用されています。
- Yao HJ et al. Three new experimental models of anterior urethral stricture in rabbits. Transl Androl Urol 11:761-772 (2022). PubMed: 35812200
- Liu T et al. MiR-4729 regulates TIE1 mRNA m6A modification and angiogenesis in hemorrhoids by targeting METTL14. Ann Transl Med 9:232 (2021). PubMed: 33708859
- Wan X et al. Hypoxia-preconditioned adipose-derived stem cells combined with scaffold promote urethral reconstruction by upregulation of angiogenesis and glycolysis. Stem Cell Res Ther 11:535 (2020). PubMed: 33308306
- Ko SF et al. Inducible pluripotent stem cell-derived mesenchymal stem cell therapy effectively protected kidney from acute ischemia-reperfusion injury. Am J Transl Res 10:3053-3067 (2018). PubMed: 30416650
- Zhang W et al. Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway. Exp Cell Res 370:333-342 (2018). PubMed: 29964051