Anti-Von Willebrand Factor 抗体 (ab96340)


  • 製品名Anti-Von Willebrand Factor antibody
    Von Willebrand Factor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Von Willebrand Factor
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Dog, Pig
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1100 - 1200 of Human Von Willebrand Factor.

  • ポジティブ・コントロール
    • This antibody gave a positive signal in Human spleen tissue lysate.



Our Abpromise guarantee covers the use of ab96340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 275 kDa (predicted molecular weight: 309 kDa).


  • 機能Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
  • 組織特異性Plasma.
  • 関連疾患Defects in VWF are the cause of von Willebrand disease (VWD) [MIM:277480]. VWD defines a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. Type I von Willebrand disease is the most common form and is characterized by partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor; type II is associated with a qualitative deficiency and functional anomalies of the Willebrand factor; type III is the most severe form and is characterized by total or near-total absence of Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII.
  • 配列類似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 4 TIL (trypsin inhibitory-like) domains.
    Contains 3 VWFA domains.
    Contains 3 VWFC domains.
    Contains 4 VWFD domains.
  • ドメインThe von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.
  • 翻訳後修飾All cysteine residues are involved in intrachain or interchain disulfide bonds.
    N- and O-glycosylated.
  • 細胞内局在Secreted. Secreted > extracellular space > extracellular matrix. Localized to storage granules.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Coagulation factor VIII antibody
    • Coagulation factor VIII VWF antibody
    • F8VWF antibody
    • Factor VIII related antigen antibody
    • von Willebrand antigen 2 antibody
    • von Willebrand antigen II antibody
    • Von Willebrand disease antibody
    • VWD antibody
    • vWF antibody
    • VWF_HUMAN antibody
    see all

Anti-Von Willebrand Factor antibody 画像

  • Anti-Von Willebrand Factor antibody (ab96340) at 1 µg/ml + Human spleen tissue lysate - total protein (ab29699) at 10 µg

    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 309 kDa
    Observed band size : 275 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 31 kDa,40 kDa,50 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 20 minutes

Anti-Von Willebrand Factor antibody (ab96340) 使用論文

ab96340 has not yet been referenced specifically in any publications.

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The following antibodies could be suitable as per your request;

Thank you for enquiry.

I am sorry to confirm that asfar as we are aware, ab96340 has never been tested in IHC-P. All tested applications are specified on our datasheets, and these are updated as soon as any new information is brought to our ...

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Vielen Dank für Ihren Anruf.

Nachdem ich wie versprochen alle unsere Von Willebrand Faktor- Antikörperdaraufhin untersucht habe, ob sie möglicherweise die Bindung von Faktor VIII inhibieren können, weiß ich nicht, ob...

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As far as I can see ab96340 should not cross react with Factor VIII. I blasted the immunogen sequence for ab96430 and only vWF came back. I also aligned the immunogen sequence to human factor VIII and there was no significant similarity.

If t...

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