Anti-Von Willebrand Factor 抗体 [36B11] (ab49706)

製品の概要

  • 製品名Anti-Von Willebrand Factor antibody [36B11]
    Von Willebrand Factor 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [36B11] to Von Willebrand Factor
  • アプリケーション適用あり: IHC-Fr, IHC-Pmore details
    適用なし: WB
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fusion protein corresponding to the A2 domain of the von Willebrand factor.

  • ポジティブ・コントロール
    • Human tonsil tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab49706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/100 - 1/200. Acetone fixation recommended.
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
    • 組織特異性Plasma.
    • 関連疾患Defects in VWF are the cause of von Willebrand disease (VWD) [MIM:277480]. VWD defines a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. Type I von Willebrand disease is the most common form and is characterized by partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor; type II is associated with a qualitative deficiency and functional anomalies of the Willebrand factor; type III is the most severe form and is characterized by total or near-total absence of Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII.
    • 配列類似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
      Contains 4 TIL (trypsin inhibitory-like) domains.
      Contains 3 VWFA domains.
      Contains 3 VWFC domains.
      Contains 4 VWFD domains.
    • ドメインThe von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.
    • 翻訳後修飾All cysteine residues are involved in intrachain or interchain disulfide bonds.
      N- and O-glycosylated.
    • 細胞内局在Secreted. Secreted > extracellular space > extracellular matrix. Localized to storage granules.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Coagulation factor VIII antibody
      • Coagulation factor VIII VWF antibody
      • F8VWF antibody
      • Factor VIII related antigen antibody
      • von Willebrand antigen 2 antibody
      • von Willebrand antigen II antibody
      • Von Willebrand disease antibody
      • VWD antibody
      • vWF antibody
      • VWF_HUMAN antibody
      see all

    Anti-Von Willebrand Factor antibody [36B11] (ab49706) 使用論文

    This product has been referenced in:
    • Vishnubalaji R  et al. In vitro differentiation of human skin-derived multipotent stromal cells into putative endothelial-like cells. BMC Dev Biol 12:7 (2012). ICC/IF ; Human . Read more (PubMed: 22280443) »

    See 1 Publication for this product

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    Vielen Dank für Ihren Anruf.

    Nachdem ich wie versprochen alle unsere Von Willebrand Faktor- Antikörperdaraufhin untersucht habe, ob sie möglicherweise die Bindung von Faktor VIII inhibieren können, weiß ich nicht, ob...

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    Thank you for contacting us.

    I am looking into adding the VW33-5 clone to our catalogue, and will e-mail you when I find out if it is available. The other clone, N10, is described in the paper at the following link. I think this must be the ...

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    Thank you for contacting Abcam.

    I wish to apologize for the delay in getting this information about ananti-Von Willebrand antibody which is specific to human and has less than 10% mouse cross reactivity.

    I have gone through each o...

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