製品の概要

  • 製品名Anti-Vitronectin antibody
    Vitronectin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Vitronectin
  • 特異性Ab28023 recognises vitronectin.
  • アプリケーション適用あり: ELISA, WB, ICC/IFmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Full length Vitronectin protein (Mouse).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab28023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/5000.
WB 1/500. Predicted molecular weight: 54 kDa.
ICC/IF 1/50.

ターゲット情報

  • 機能Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
    Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
  • 組織特異性Plasma.
  • 配列類似性Contains 4 hemopexin repeats.
    Contains 1 SMB (somatomedin-B) domain.
  • ドメインThe SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
  • 翻訳後修飾Sulfated on 2 tyrosine residues.
    N- and O-glycosylated.
    Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
    It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
    Phosphorylation sites are present in the extracellular medium.
  • 細胞内局在Secreted, extracellular space.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Complement S Protein antibody
    • Epibolin antibody
    • S Protein antibody
    • S-protein antibody
    • Serum Spreading Factor antibody
    • Serum-spreading factor antibody
    • Somatomedin B antibody
    • Somatomedin-B antibody
    • V75 antibody
    • Vitronectin V10 subunit antibody
    • Vitronectin V65 subunit antibody
    • VN antibody
    • VNT antibody
    • VTN antibody
    • VTNC_HUMAN antibody
    see all

Anti-Vitronectin antibody (ab28023) 使用論文

This product has been referenced in:
  • Malhotra D  et al. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol 13:499-510 (2012). IHC-FoFr ; Mouse . Read more (PubMed: 22466668) »
  • Mesnard L  et al. Vitronectin dictates intraglomerular fibrinolysis in immune-mediated glomerulonephritis. FASEB J 25:3543-53 (2011). Read more (PubMed: 21764994) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"