製品の概要

  • 製品名Anti-Vitronectin antibody [A18]
    Vitronectin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [A18] to Vitronectin
  • 特異性ab23444 is highly specific for Vitronectin. There is no evidence for cross reactivity with other connective tissue proteins (Fibronectin, Elastin, Collagen, Laminin).
  • アプリケーション適用あり: IHC-P, Inhibition Assay, ELISA, IHC-Frmore details
    適用なし: WB
  • 種交差性
    交差種: Rabbit, Horse, Cow
    非交差種: Sheep, Human
  • 免疫原

    Tissue/ cell preparation (Cow): Lysed bovine corneal endothelial cells and extracellular matrix

  • 特記事項

    ab23444 can be used to probe vitronectin conformation.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 15mM Sodium Azide
    Constituents: 500mM Sodium chloride, 10mM PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノモノクローナル
  • クローン名A18
  • ミエローマSp2/0
  • アイソタイプIgG1
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab23444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration.

ab23444 inhibits integrin mediated cell adhesion to bovine vitronectin.

ELISA 1/500.
IHC-Fr 1/500.

1/500 for PLP fixed samples.

  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
      Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
    • 組織特異性Plasma.
    • 配列類似性Contains 4 hemopexin repeats.
      Contains 1 SMB (somatomedin-B) domain.
    • ドメインThe SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
    • 翻訳後修飾Sulfated on 2 tyrosine residues.
      N- and O-glycosylated.
      Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
      It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
      Phosphorylation sites are present in the extracellular medium.
    • 細胞内局在Secreted, extracellular space.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Complement S Protein antibody
      • Epibolin antibody
      • S Protein antibody
      • S-protein antibody
      • Serum Spreading Factor antibody
      • Serum-spreading factor antibody
      • Somatomedin B antibody
      • Somatomedin-B antibody
      • V75 antibody
      • Vitronectin V10 subunit antibody
      • Vitronectin V65 subunit antibody
      • VN antibody
      • VNT antibody
      • VTN antibody
      • VTNC_HUMAN antibody
      see all

    Anti-Vitronectin antibody [A18] (ab23444) 使用論文

    ab23444 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab23444.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"