Anti-Vitamin D Receptor (phospho S51) 抗体 (ab79311)

製品の概要

  • 製品名Anti-Vitamin D Receptor (phospho S51) antibody
    Vitamin D Receptor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Vitamin D Receptor (phospho S51)
  • 特異性ab79311 detects endogenous levels of Vitamin D3 Receptor only when phosphorylated at serine 51.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthesized phosphopeptide derived from human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-SP-M-K).

  • ポジティブ・コントロール
    • COLO cell extract treated with insulin (0.01U/ml for 15mins).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab79311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 48 kDa).
ELISA 1/20000.

ターゲット情報

  • 機能Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
  • 関連疾患Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1 25 dihydroxyvitamin D3 receptor antibody
    • 1 antibody
    • 1,25 dihydroxyvitamin D3 receptor antibody
    • 1,25-@dihydroxyvitamin D3 receptor antibody
    • 25-dihydroxyvitamin D3 receptor antibody
    • Member 1 antibody
    • NR1I1 antibody
    • Nuclear receptor subfamily 1 group I member 1 antibody
    • PPP1R163 antibody
    • Protein phosphatase 1, regulatory subunit 163 antibody
    • VDR antibody
    • VDR_HUMAN antibody
    • Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
    • Vitamin D hormone receptor antibody
    • Vitamin D nuclear receptor variant 1 antibody
    • Vitamin D receptor antibody
    • Vitamin D3 receptor antibody
    see all

Anti-Vitamin D Receptor (phospho S51) antibody 画像

  • All lanes : Anti-Vitamin D Receptor (phospho S51) antibody (ab79311) at 1/500 dilution

    Lane 1 : COLO cells extract treated with insulin (0.01U/ml, 15mins)
    Lane 2 : COLO cells extract treated with insulin (0.01U/ml, 15mins) with Immunizing phosphopeptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)

Anti-Vitamin D Receptor (phospho S51) antibody (ab79311) 使用論文

ab79311 has not yet been referenced specifically in any publications.

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