Anti-Viral Protein U 抗体 (ab81532)

製品の概要

• 製品名Anti-Viral Protein U antibody
• 製品の詳細
  Rabbit polyclonal to Viral Protein U
• アプリケーション適用あり: ELISA, WB, ICC/IF, IPmore details
• 種交差性
  Reacts with HIV1.
• 免疫原

  Synthetic peptide:

  EGDQEELSALMEMGHHAPWNVND

  , corresponding to amino acids 58-80 of Viral Protein U, post-synthetically modified to achieve highest antigenicity and coupled to KLH using heterobifunctional cross linker.
  Run BLAST with Run BLAST with

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファーPreservative: 0.02% Sodium Azide
  Proprietary antibody stabilization buffer.
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Microbiology
  • Organism
  • Virus
  • RNA Virus
  • ssRNA positive strand virus
  • HIV

  • Immunology
  • Immune System Diseases
  • Antiviral Signaling
  • HIV

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 関連性Retroviruses have several characteristic structural and catalytic proteins. One such auxiliary protein is a viral protein U (Vpu) which enhances virion release from human cells and is also involved in the degradation of CD4, the cellular surface receptor of HIV-1. The Vpu has no homolog in less pathogenic HIV-2 virus. Vpu is an 81 amino acid class I membrane integral protein that is unique to human and simian immunodeficiency virus isolated from Chimpanzee and a few other monkey species. The 16kDa protein Vpu protein consists of an N-terminal hydrophobic membrane anchor of 27 amino acids and a charged C-terminal hydrophilic domain of 54 amino acids that extents to the cytoplasm. The cytoplasmic domain has a conserved dual serine phosphorylation site (S52 GXX and S56 motif) that is phosphorylated by casein kinase II. Vpu is involved in viral replication and degradation of its cellular receptor CD4 and enhancement of viral particle release from macrophages and primary lymphocytes.
• 細胞内局在Membrane; Single-pass type I membrane protein.
• 別名
  • U ORF protein antibody
  • Vpu antibody