Anti-Vimentin 抗体 [VI-01] (Dyomics® 547) (ab38873)


  • 製品名Anti-Vimentin antibody [VI-01] (Dyomics® 547)
    Vimentin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [VI-01] to Vimentin (Dyomics® 547)
  • 標識Dyomics® 547
  • 特異性This antibody is specific for Vimentin. Cross-reactivity was found with smooth muscle desmin.
  • アプリケーション適用あり: ICCmore details
  • 種交差性
    Reacts with all species.
  • 免疫原

    Pellet of pig brain cold stable proteins after depolymerization of microtubules.

  • 特記事項

    The conjugate is purified by size chromatography and adjusted for direct use.



Our Abpromise guarantee covers the use of ab38873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報ICC on fixed and permeabilized cells: 1/50.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
      Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
    • 組織特異性Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
    • 関連疾患Cataract 30
    • 配列類似性Belongs to the intermediate filament family.
    • ドメインThe central alpha-helical coiled-coil rod region mediates elementary homodimerization.
      The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
    • 翻訳後修飾Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
      O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.
      S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 製品の状態Vimentin is found in connective tissue and in the cytoskeleton.
    • 別名
      • CTRCT30 antibody
      • Epididymis luminal protein 113 antibody
      • FLJ36605 antibody
      • HEL113 antibody
      • VIM antibody
      • VIME_HUMAN antibody
      • Vimentin antibody
      see all

    Anti-Vimentin antibody [VI-01] (Dyomics® 547) 画像

    • Immunofluorescence staining of 3T3 mouse embryonal fibroblast cell line with ab38873 anti-Vimentin (VI-01) Dyomics® 547. Nuclei are stained with DAPI (blue).

      Cells were fixed with methanol for 10 minutes at -20°C.

    Anti-Vimentin antibody [VI-01] (Dyomics® 547) (ab38873) 使用論文

    ab38873 has not yet been referenced specifically in any publications.

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