製品の概要

  • 製品名
    Anti-VEGFR 1+VEGFR 2 antibody
  • 製品の詳細
    Rabbit polyclonal to VEGFR 1+VEGFR 2
  • 特異性
    This antibody is specific for VEGFR 1 with significant cross-reactivity with the VEGFR 2 protein.
  • アプリケーション
    適用あり: WB, ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Mouse VEGFR 1+VEGFR 2 aa 800-900.
    Sequence:

    PDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK VVQASAFG IKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGAC TK

  • ポジティブ・コントロール
    • HUVEC lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab36844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/2000. Predicted molecular weight: 150 kDa.
ICC/IF 1/500.
IHC-P 1/250 - 1/500.

ターゲット情報

  • 関連性
    Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
  • 細胞内局在
    Cell Membrane
  • 参照データベース
  • 別名
    • FLK1 antibody
    • FLT1 antibody
    • KDR antibody
    • Kinase insert domain receptor antibody
    • Vascular endothelial growth factor receptor 1 antibody
    • Vascular endothelial growth factor receptor 2 antibody
    • Vascular permeability factor receptor antibody
    • VEGFR antibody
    • VEGFR1 antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Nusrat O  et al. The Role of Angiogenesis in the Persistence of Chemoresistance in Epithelial Ovarian Cancer. Reprod Sci 23:1484-1492 (2016). Read more (PubMed: 27122375) »
  • Shi J  et al. Xiaotan Sanjie decoction inhibits angiogenesis in gastric cancer through Interleukin-8-linked regulation of the vascular endothelial growth factor pathway. J Ethnopharmacol 189:230-7 (2016). Read more (PubMed: 27224240) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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