製品の概要

  • 製品名Anti-VEGFC antibody [9/E7]
    VEGFC 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [9/E7] to VEGFC
  • アプリケーション適用あり: IHC-P, WB, IHC-Frmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Recombinant fragment (His-tag) corresponding to Human VEGFC aa 103-215.
    Database link: P49767

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 2 - 10 µg/ml.
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 47 kDa.
IHC-Fr Use a concentration of 2 - 10 µg/ml.

ターゲット情報

  • 機能Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
  • 組織特異性Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
  • 配列類似性Belongs to the PDGF/VEGF growth factor family.
  • 翻訳後修飾Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Flt 4L antibody
    • Flt4 ligand antibody
    • FLT4 ligand DHM antibody
    • Flt4-L antibody
    • Flt4L antibody
    • Vascular endothelial growth factor C antibody
    • Vascular endothelial growth factor related protein antibody
    • Vascular endothelial growth factor-related protein antibody
    • VEGF C antibody
    • VEGF-C antibody
    • Vegfc antibody
    • VEGFC_HUMAN antibody
    • VRP antibody
    see all

Anti-VEGFC antibody [9/E7] 画像

  • Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.

  • Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue sections labelling VEGFC with ab106512.

Anti-VEGFC antibody [9/E7] (ab106512) 使用論文

ab106512 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab106512.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"