Anti-VEGFC 抗体 [9/E7] (ab106512)
Key features and details
- Mouse monoclonal [9/E7] to VEGFC
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Rat, Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-VEGFC antibody [9/E7]
VEGFC 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [9/E7] to VEGFC -
由来種
Mouse -
アプリケーション
適用あり: IHC-P, IHC-Frmore details -
種交差性
交差種: Rat, Human -
免疫原
Recombinant fragment (His-tag) corresponding to Human VEGFC aa 103-215.
Database link: P49767 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Lyophilized:Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
9/E7 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106512の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
Use a concentration of 2 - 10 µg/ml.
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IHC-Fr |
Use a concentration of 2 - 10 µg/ml.
|
特記事項 |
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IHC-P
Use a concentration of 2 - 10 µg/ml. |
IHC-Fr
Use a concentration of 2 - 10 µg/ml. |
ターゲット情報
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機能
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. -
組織特異性
Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. -
配列類似性
Belongs to the PDGF/VEGF growth factor family. -
翻訳後修飾
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 7424 Human
- Entrez Gene: 114111 Rat
- Omim: 601528 Human
- SwissProt: P49767 Human
- SwissProt: Q6FH59 Human
- SwissProt: O35757 Rat
- Unigene: 435215 Human
- Unigene: 6913 Rat
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別名
- Flt 4L antibody
- Flt4 ligand antibody
- FLT4 ligand DHM antibody
see all
画像
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Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.
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Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue sections labelling VEGFC with ab106512.
データシートおよび資料
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Datasheet download
参考文献 (3)
ab106512 は 3 報の論文で使用されています。
- Kusumoto S et al. An immature inhibin-a-expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis. Cancer Med 10:1485-1500 (2021). PubMed: 33611864
- Liu X et al. Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels. Acta Neuropathol Commun 8:16 (2020). PubMed: 32059751
- Loessner D et al. A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns. Biomaterials 190-191:63-75 (2019). PubMed: 30396040