製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to VDAC2
  • アプリケーション
    適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide

    GHKVGLALELEA

    , corresponding to C terminal amino acids 298-309 of Human VDAC2 Isoform 1.

  • ポジティブ・コントロール
    • Human testis lysate, Human heart tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 32 kDa.
ELISA 1/64000.
IHC-P Use a concentration of 2.5 - 5 µg/ml.

ターゲット情報

  • 機能
    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
  • 組織特異性
    Expressed in all tissues examined.
  • 配列類似性
    Belongs to the eukaryotic mitochondrial porin family.
  • ドメイン
    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • 細胞内局在
    Mitochondrion outer membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • B-36 vdac antibody
    • FLJ23841 antibody
    • hVDAC2 antibody
    • OTTHUMP00000019878 antibody
    • OTTHUMP00000019879 antibody
    • OTTHUMP00000019880 antibody
    • Outer mitochondrial membrane protein porin 2 antibody
    • POR antibody
    • Porin-2 antibody
    • VDAC 2 antibody
    • VDAC-2 antibody
    • VDAC2 antibody
    • VDAC2_HUMAN antibody
    • Vdac6 antibody
    • Voltage dependent anion channel 2 antibody
    • Voltage dependent anion selective channel protein 2 antibody
    • Voltage-dependent anion-selective channel protein 2 antibody
    see all

Anti-VDAC2 antibody 画像

  • Immunohistochemical staining of ab118872 at 5 µg/ml staining VDAC2 in Paraffin-embedded Human heart tissue followed by biotinylated anti-Goat IgG secondary antibody, alkaline phosphatasestreptavidin and chromogen
  • Anti-VDAC2 antibody (ab118872) at 0.3 µg/ml + Human testis lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 32 kDa

Anti-VDAC2 antibody (ab118872) 使用論文

This product has been referenced in:
  • Triplett JC  et al. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta 1852:2213-24 (2015). Read more (PubMed: 26248058) »
  • Tanno M  et al. Translocation of glycogen synthase kinase-3ß (GSK-3ß), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2). J Biol Chem 289:29285-96 (2014). Read more (PubMed: 25187518) »

See all 2 Publications for this product

Product Wall

Thank you for contacting us. Unfortunately, both VDAC1 and VDAC3 are very homologous with VDAC2. While we have not tested these antibodies specifically for cross-reactivity with VDAC1 and VDAC3, the antibodies ab37985 and ab118872 show ˜67% homology wi...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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