Anti-VDAC1/Porin 抗体 [16G9E6BC4] - Mitochondrial Loading Control (ab110326)

製品の概要

  • 製品名
    Anti-VDAC1/Porin antibody [16G9E6BC4] - Mitochondrial Loading Control
    VDAC1/Porin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [16G9E6BC4] to VDAC1/Porin - Mitochondrial Loading Control
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Saccharomyces cerevisiae
  • 免疫原

    Full length native protein (purified) corresponding to Saccharomyces cerevisiae VDAC1/Porin.

  • 特記事項

    This antibody clone is manufactured by Abcam.

    Product was previously marketed under the MitoSciences sub-brand.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110326 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa.

ターゲット情報

  • 機能
    Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
  • 組織特異性
    Heart, liver and skeletal muscle.
  • 配列類似性
    Belongs to the eukaryotic mitochondrial porin family.
  • ドメイン
    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
  • 細胞内局在
    Mitochondrion outer membrane. Cell membrane.
  • Information by UniProt
  • 参照データベース
    • 別名
      • N2441 antibody
      • OMP2 antibody
      • POR1 antibody
      • hVDAC1 antibody
      • MGC111064 antibody
      • Mitochondrial Porin antibody
      • Outer mitochondrial membrane protein porin 1 antibody
      • Plasmalemmal porin antibody
      • Porin 31HL antibody
      • Porin 31HM antibody
      • VDAC antibody
      • VDAC-1 antibody
      • Vdac1 antibody
      • VDAC1_HUMAN antibody
      • Voltage dependent anion channel 1 antibody
      • Voltage dependent anion selective channel protein 1 antibody
      • Voltage-dependent anion-selective channel protein 1 antibody
      • YNL055C antibody
      • YNL2441C antibody
      see all

    画像

    • Anti-VDAC1/Porin antibody [16G9E6BC4] - Mitochondrial Loading Control (ab110326) at 1 µg/ml + Yeast spheroplast membrane fraction.

      Predicted band size : 30 kDa

    プロトコール

    参考文献

    This product has been referenced in:
    • Ying G  et al. Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors. PLoS One 11:e0161236 (2016). Read more (PubMed: 27529348) »
    • Soloveychik M  et al. Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation. Sci Rep 6:37942 (2016). WB ; Saccharomyces cerevisiae . Read more (PubMed: 27897198) »

    See all 17 Publications for this product

    レビューと Q&A

    Abcam has not validated the combination of species/application used in this Abreview.
    Application
    Immunohistochemistry (Frozen sections)
    Blocking step
    Serum as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
    Sample
    Mouse Tissue sections (Brain)
    Specification
    Brain
    Permeabilization
    Yes - 0.3% Triton X-100
    Fixative
    Paraformaldehyde
    Username

    Prof. Chichung Lie

    Verified customer

    投稿 Aug 01 2013

    Thank you for your enquiry.
    Currently, this antibody (ab34726) is out of stock. However, the good news is that we have some alternative products against the same target protein (VDAC/Porin). I do not know in which species/application your customer...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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