製品の概要

  • 製品名
    Anti-VAP1 antibody [7-88]
    VAP1 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [7-88] to VAP1
  • アプリケーション
    適用あり: IHC-Fr, Functional Studies, Flow Cyt, ICC/IF, IPmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Tissue/ cell preparation of vessels from Mouse lymph nodes

  • ポジティブ・コントロール
    • Mouse spleen Mouse VAP-1-transfected CHO cells
  • 特記事項


    Inhibits migration of granulocytes and monocytes in acute models of inflammation.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab81673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/50.
Functional Studies Use at an assay dependent concentration. Antibody 7-88 (200µg) was intravenously injected which resulted in the inhibition of leukocyte trafficking in inflamed peritoneum.
Flow Cyt 1/50. ab18536-Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
ICC/IF 1/50.
IP Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.
  • 組織特異性
    Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis.
  • 配列類似性
    Belongs to the copper/topaquinone oxidase family.
  • 翻訳後修飾
    Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
    N- and O-glycosylated.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Amine oxidase, copper containing 3 (vascular adhesion protein 1) antibody
    • AOC3 antibody
    • AOC3_HUMAN antibody
    • Copper amine oxidase antibody
    • HPAO antibody
    • Membrane copper amine oxidase antibody
    • Membrane primary amine oxidase antibody
    • Semicarbazide sensitive amine oxidase antibody
    • Semicarbazide-sensitive amine oxidase antibody
    • SSAO antibody
    • VAP-1 antibody
    • Vascular adhesion protein 1 antibody
    • VP97 antibody
    see all

画像

  • ab81673 staining VAP1 in mouse muscle tissue by Immunohistochemistry (Frozen sections).

参考文献

This product has been referenced in:
  • Yoshikawa N  et al. Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization. Mol Vis 18:593-600 (2012). ICC/IF ; Mouse . Read more (PubMed: 22419852) »
  • Merinen M  et al. Vascular adhesion protein-1 is involved in both acute and chronic inflammation in the mouse. Am J Pathol 166:793-800 (2005). Flow Cyt, Functional Studies, IHC-Fr ; Mouse . Read more (PubMed: 15743791) »

See all 4 Publications for this product

レビューと Q&A

Thank you for having followed this up with the customer.

Indeed, the protocol seems to me to be intermediate in the fixation with paraffin embedded tissues, where the tissues are often fixed overnight in PFA, and with frozen sections, where t...

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I have looked through the protocol and have on...

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