製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to VANGL1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 7-56 (YSGYSYYSSH SKKSHRQGER TRERHKSPRN KDGRGSEKSV TIQPPTGEPL) of Human VANGL1 (NP_620409).

  • ポジティブ・コントロール
    • RPMI-8226 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 組織特異性
    Accordiing to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.
  • 関連疾患
    Defects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis).
    Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM) [MIM:600145]. SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant.
  • 配列類似性
    Belongs to the Vang family.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ANGL planar cell polarity protein 1 antibody
    • KAI1 C-terminal interacting tetraspanin antibody
    • KITENIN antibody
    • Loop tail protein 2 homolog antibody
    • Loop-tail protein 2 homolog antibody
    • LPP2 antibody
    • MGC5338 antibody
    • STB2 antibody
    • STBM2 antibody
    • Strabismus 2 antibody
    • Strabismus, Drosophila, homolog of, 2 antibody
    • Van Gogh like protein 1 antibody
    • Van Gogh, Drosophila, homolog of, 1 antibody
    • Van Gogh-like protein 1 antibody
    • Vang like 1 (van gogh, Drosophila) antibody
    • Vang like protein 1 antibody
    • Vang-like 1 antibody
    • Vang-like protein 1 antibody
    • VANG1_HUMAN antibody
    • VANGL 1 antibody
    • Vangl1 antibody
    see all

Anti-VANGL1 antibody 画像

  • Anti-VANGL1 antibody (ab123045) at 1 µg/ml + RPMI-8226 cell lysate at 10 µg

    Predicted band size : 60 kDa

プロトコール

Anti-VANGL1 antibody (ab123045) 使用論文

ab123045 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application
Western blot
Sample
Mouse Cell lysate - whole cell (uterus)
Gel Running Conditions
Reduced Denaturing (8%, SGS gel)
Loading amount
30 µg
Treatment
Wild Type and Vangl1 KO
Specification
uterus
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Username

Dr. Sudhansu Dey

Verified customer

投稿 Oct 05 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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