製品の概要

  • 製品名Anti-UXT antibody
    UXT 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to UXT
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    A 14-22 amino acid region within synthetic peptide: MATPPKRRAV EATGEKVLRY ETFISDVLQR DLRKVLDHRD KVYEQLAKYL, corresponding to N terminal amino acids 1-50 of Human UXT

  • ポジティブ・コントロール
    • HepG2 cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab65540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 18 kDa (predicted molecular weight: 18 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/312500.

ターゲット情報

  • 機能Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.
  • 組織特異性Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.
  • 配列類似性Belongs to the UXT family.
  • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Androgen receptor trapped clone 27 protein antibody
    • ART 27 antibody
    • ART-27 antibody
    • OTTHUMP00000023226 antibody
    • OTTHUMP00000023227 antibody
    • Protein UXT antibody
    • SKP2 associated alpha PFD 1 antibody
    • STAP1 antibody
    • Ubiquitously expressed prefoldin like chaperone antibody
    • Ubiquitously expressed transcript antibody
    • Ubiquitously expressed transcript protein antibody
    • Uxt antibody
    • UXT_HUMAN antibody
    see all

Anti-UXT antibody 画像

  • Anti-UXT antibody (ab65540) at 2.5 µg/ml + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 18 kDa
    Observed band size : 18 kDa
    Additional bands at : 19 kDa. We are unsure as to the identity of these extra bands.

Anti-UXT antibody (ab65540) 使用論文

ab65540 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"