Anti-USP46 抗体 (ab88795)
Key features and details
- Mouse polyclonal to USP46
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-USP46 antibody
USP46 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to USP46 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein within Human USP46. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab88795の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB | (1) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa.
|
特記事項 |
---|
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. |
ターゲット情報
-
機能
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. -
組織特異性
Broadly expressed. -
配列類似性
Belongs to the peptidase C19 family. USP12/USP46 subfamily. - Information by UniProt
-
参照データベース
- Entrez Gene: 64854 Human
- Omim: 612849 Human
- SwissProt: P62068 Human
- Unigene: 7966 Human
-
別名
- Deubiquitinating enzyme 46 antibody
- FLJ11850 antibody
- FLJ12552 antibody
see all
画像
-
Anti-USP46 antibody (ab88795) at 1 µg/ml + human kidney tissue lysate at 50 µg
Predicted band size: 42 kDa
Observed band size: 35 kDa why is the actual band size different from the predicted? -
All lanes : Anti-USP46 antibody (ab88795) at 1 µg/ml
Lane 1 : USP46 transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 42 kDa
Observed band size: 37 kDa why is the actual band size different from the predicted?
プロトコール
データシートおよび資料
-
Datasheet download
参考文献 (3)
ab88795 は 3 報の論文で使用されています。
- Ye X et al. CircRNA circ-NNT mediates myocardial ischemia/reperfusion injury through activating pyroptosis by sponging miR-33a-5p and regulating USP46 expression. Cell Death Discov 7:370 (2021). PubMed: 34845193
- Wang W et al. USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway. Biomed Res Int 2020:2509529 (2020). PubMed: 33029497
- Zhang Y et al. Amyloid-ß Induces AMPA Receptor Ubiquitination and Degradation in Primary Neurons and Human Brains of Alzheimer's Disease. J Alzheimers Dis 62:1789-1801 (2018). PubMed: 29614651