製品の概要

  • 製品名Anti-USP33 antibody
    USP33 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to USP33
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to USP33 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • ポジティブ・コントロール
    • Human kidney tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab62052 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the peptidase C19 family. USP20/USP33 subfamily.
    Contains 2 DUSP domains.
    Contains 1 UBP-type zinc finger.
  • ドメインThe UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 86 is replaced by a Glu residue.
  • 翻訳後修飾Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
  • 細胞内局在Cytoplasm > perinuclear region. According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Deubiquitinating enzyme 33 antibody
    • EC 3 1 2 15 antibody
    • hVDU1 antibody
    • KIAA1097 antibody
    • MGC16868 antibody
    • OTTHUMP00000011234 antibody
    • OTTHUMP00000011330 antibody
    • OTTHUMP00000011331 antibody
    • pVHL interacting deubiquitinating enzyme 1 antibody
    • Ubiquitin carboxyl terminal hydrolase 33 antibody
    • Ubiquitin carboxyl-terminal hydrolase 33 antibody
    • Ubiquitin specific peptidase 33 antibody
    • Ubiquitin specific processing protease 33 antibody
    • ubiquitin specific protease 33 antibody
    • Ubiquitin thioesterase 33 antibody
    • Ubiquitin thiolesterase 33 antibody
    • Ubiquitin-specific-processing protease 33 antibody
    • UBP33_HUMAN antibody
    • USP 33 antibody
    • Usp33 antibody
    • VDU 1 antibody
    • VDU1 antibody
    • VHL interacting deubiquitinating enzyme 1 antibody
    • VHL-interacting deubiquitinating enzyme 1 antibody
    see all

Anti-USP33 antibody 画像

  • ab62052, at 5µg/ml, staining USP33 in Formalin/PFA-Fixed Paraffin-Embedded Human Kidney tissue by Immunohistochemistry.

Anti-USP33 antibody (ab62052) 使用論文

ab62052 has not yet been referenced specifically in any publications.

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