製品の概要

  • 製品名Anti-USP20 antibody
    USP20 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to USP20
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: VATVALTEAR DSDSSDTDEK REGDRSPSED EFLSCDSSSD RGEGDGQGRG GGSSQAETEL LIPDEAGRAI SEKERMKDRK FSWGQQRTNS EQVDEDAD, corresponding to amino acids 252-350 of Human USP20

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56789 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
    • 配列類似性Belongs to the peptidase C19 family. USP20/USP33 subfamily.
      Contains 2 DUSP domains.
      Contains 1 UBP-type zinc finger.
    • ドメインThe UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue.
    • 翻訳後修飾Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
    • 細胞内局在Cytoplasm > perinuclear region. According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Deubiquitinating enzyme 20 antibody
      • hVDU2 antibody
      • KIAA1003 antibody
      • LSFR 3A antibody
      • LSFR3A antibody
      • pVHL interacting deubiquitinating enzyme 2 antibody
      • Ubiquitin carboxyl terminal hydrolase 20 antibody
      • Ubiquitin carboxyl-terminal hydrolase 20 antibody
      • ubiquitin specific peptidase 20 antibody
      • Ubiquitin specific processing protease 20 antibody
      • Ubiquitin specific protease 20 antibody
      • Ubiquitin thioesterase 20 antibody
      • Ubiquitin thiolesterase 20 antibody
      • Ubiquitin-specific-processing protease 20 antibody
      • UBP20_HUMAN antibody
      • USP 20 antibody
      • USP20 antibody
      • VDU 2 antibody
      • VDU2 antibody
      • VHL interacting deubiquitinating enzyme 2 antibody
      • VHL-interacting deubiquitinating enzyme 2 antibody
      see all

    Anti-USP20 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab56789 USP20 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-USP20 antibody (ab56789) 使用論文

    ab56789 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab56789.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"