Anti-USP10 抗体 (ab72486)
Key features and details
- Rabbit polyclonal to USP10
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-USP10 antibody
USP10 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to USP10 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab72486の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000. Predicted molecular weight: 87 kDa.
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特記事項 |
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WB
1/1000. Predicted molecular weight: 87 kDa. |
ターゲット情報
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機能
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. -
組織特異性
Widely expressed. -
配列類似性
Belongs to the peptidase C19 family. USP10 subfamily. -
翻訳後修飾
Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus. -
細胞内局在
Cytoplasm. Nucleus. Early endosome. Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM. - Information by UniProt
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参照データベース
- Entrez Gene: 9100 Human
- Omim: 609818 Human
- SwissProt: Q14694 Human
- Unigene: 136778 Human
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別名
- Deubiquitinating enzyme 10 antibody
- KIAA0190 antibody
- MGC124997 antibody
see all
画像
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All lanes : Anti-USP10 antibody (ab72486) at 1/1000 dilution
Lane 1 : HEK293
Lane 2 : HEK293/USP10
Predicted band size: 87 kDa
Observed band size: 100 kDa why is the actual band size different from the predicted?
データシートおよび資料
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Datasheet download
参考文献 (15)
ab72486 は 15 報の論文で使用されています。
- Bhattacharya U et al. The deubiquitinase USP10 protects pancreatic cancer cells from endoplasmic reticulum stress. NPJ Precis Oncol 6:93 (2022). PubMed: 36543867
- Wang X et al. The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis. Cell Death Differ 27:1747-1764 (2020). PubMed: 31748695
- Zhu H et al. USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ. Cancer Res 80:2204-2216 (2020). PubMed: 32217697
- Kim K et al. Prognostic significance of USP10 and p14ARF expression in patients with colorectal cancer. Pathol Res Pract 216:152988 (2020). PubMed: 32362421
- Xie W et al. Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34. Cell Rep 30:2807-2819.e4 (2020). PubMed: 32101753