製品の概要

  • 製品名Anti-USP10 antibody
    USP10 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to USP10
  • アプリケーション適用あり: ICC, WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to N terminal residues of Human USP10 (CAB82392.2).

  • ポジティブ・コントロール
    • Human brain (cortex), colon and breast tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab117606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 87 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the peptidase C19 family. USP10 subfamily.
  • 翻訳後修飾Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.
  • 細胞内局在Cytoplasm. Nucleus. Early endosome. Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Deubiquitinating enzyme 10 antibody
    • KIAA0190 antibody
    • MGC124997 antibody
    • MGC2621 antibody
    • Ubiquitin carboxyl terminal hydrolase 10 antibody
    • Ubiquitin carboxyl-terminal hydrolase 10 antibody
    • Ubiquitin specific peptidase 10 antibody
    • Ubiquitin specific processing protease 10 antibody
    • Ubiquitin specific protease 10 antibody
    • Ubiquitin thioesterase 10 antibody
    • Ubiquitin thiolesterase 10 antibody
    • Ubiquitin-specific-processing protease 10 antibody
    • UBP10_HUMAN antibody
    • UBPO antibody
    • USP 10 antibody
    • USP10 antibody
    see all

Anti-USP10 antibody 画像

  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Brain (cortex) tissue by Immunohistochemistry.
  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Breast tissue by Immunohistochemistry.
  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Colon tissue by Immunohistochemistry.

Anti-USP10 antibody (ab117606) 使用論文

ab117606 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"