製品の概要

  • 製品名Anti-USP1 antibody
    USP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to USP1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residue 450 and 500 of human USP1 (NP_003359.3)

  • ポジティブ・コントロール
    • Human controls: Anaplastic Thyroid Carcinoma, Breast Carcinoma, Prostate Carcinoma, Small Cell Lung Cancer

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500.
    Epitope exposure is recommended.
    Epitope exposure with citrate or tris-EDTA pH9.0 buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
    • 配列類似性Belongs to the peptidase C19 family.
    • 発生段階Cell cycle-regulated. Highest level during S phase.
    • 翻訳後修飾Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
      Ubiquitinated; leading to its subsequent proteasomal degradation.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Deubiquitinating enzyme 1 antibody
      • hUBP antibody
      • Ubiquitin carboxyl terminal hydrolase 1 antibody
      • Ubiquitin carboxyl-terminal hydrolase 1 antibody
      • Ubiquitin specific peptidase 1 antibody
      • Ubiquitin specific protease 1 antibody
      • Ubiquitin thioesterase 1 antibody
      • Ubiquitin thiolesterase 1 antibody
      • Ubiquitin-specific-processing protease 1 antibody
      • UBP antibody
      • UBP1_HUMAN antibody
      • USP 1 antibody
      • Usp1 antibody
      see all

    Anti-USP1 antibody 画像

    • Staining of USP1 by Immunohistochemistry on a formalin fixed, paraffin embedded section of human thyroid carcinoma using a 1/250 dilution of ab84772. Detection: DAB staining

    Anti-USP1 antibody (ab84772) 使用論文

    ab84772 has not yet been referenced specifically in any publications.

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