Anti-USH2A 抗体 (ab42131)

製品の概要

• 製品名
  Anti-USH2A antibody
  USH2A 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to USH2A
• 特異性
  The antibody does not cross reacts with any other protein in RPE cells.
• アプリケーション
  適用あり: WB, IPmore details
• 種交差性
  交差種: Rat, Human
  
• 免疫原

  Synthetic cyclic peptide:

  LTN REI LEV FSG DLL RLH AQS HC

  , corresponding to internal/mid region amino acids 280-302 of human USH2A.

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • This antibody strongly labels a 186 kDa protein in RPE (retinal pigment epithelium) cell extracts.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Antibody stabilization buffer, with preservatives, consisting of Hepes, NaCl, KCl, glycerol, BSA and chaotropic agents. Preservative: 0.01% Thimerosal (merthiolate)
  
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Neuroscience
  • Sensory System
  • Visual system

  • Neuroscience
  • Sensory System
  • Auditory system

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 関連性
  The Usher 2A gene expresses an extra cellular matrix protein that resembles unconventional Myosin and do not appear to have any un-conventional functional correlations. It is expressed primarily in retina and cochlea and may be important in the development and homeostasis of the inner ear and retina. The human Usher Syndrome 2A (Ush2A) protein has several functional domains (Laminin type EGF like domain; Laminin-Type epidermal growth factor like domain and a fibronectin type 3 like domain). The protein has a single transmembrane domain that anchor the protein to the cell membrane, the rest of the protein stays outside the cell. Defects in the USH2A gene are the most common cause of deafness and blindness in adults and affect 3-6% children born with hearing impairments. The affected individuals have sensory-neural deficiencies at birth and subsequently develop progressive retinitis pigmentosa (RP). Three forms of Usher syndrome have been characterized, Usher Type 1, II and III which can be distinguish based on severity of hearing loss and vestibular involvement. Type I patents are profoundly deaf while type II (most common form of Usher syndrome) patients are mildly deaf but have normal in vestibular responses.
• 細胞内局在
  Cell Membrane; single-pass type I membrane protein. Isoform 2 is secreted.
• 参照データベース
  • Entrez Gene: 7399 Human
  • Entrez Gene: 266765 Rat
  • Omim: 608400 Human
  • SwissProt: O75445 Human
  • SwissProt: Q8K3K1 Rat
  • Unigene: 655974 Human
• 別名
  • dJ1111A8.1 antibody
  • US2 antibody
  • USH2A antibody

  • Usher syndrome type 2A protein antibody
  • Usher syndrome type IIa protein antibody
  • Usherin antibody

  see all

プロトコール

• Western blot protocols
• Immunoprecipitation protocols