製品の概要

  • 製品名Anti-URP2 antibody
    URP2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to URP2
  • 特異性ab106741 is expected to recognize both isoforms (NP_113659.3, NP_848537.1).
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-ERARGEELDED

    , corresponding to C terminal amino acids 645-655 of Human URP2 (NP_848537.1).

  • ポジティブ・コントロール
    • Human Peripheral Blood Mononucleocytes lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 76 kDa.

ターゲット情報

  • 機能Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).
    Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
  • 組織特異性Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
  • 関連疾患Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3) [MIM:612840]; also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes.
  • 配列類似性Belongs to the kindlin family.
    Contains 1 FERM domain.
    Contains 1 PH domain.
  • ドメインThe FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
  • 細胞内局在Cell projection > podosome. Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Fermitin family homolog 3 antibody
    • Fermitin family member 3 antibody
    • FERMT3 antibody
    • Kind3 antibody
    • Kindlin 3 antibody
    • Kindlin-3 antibody
    • Kindlin3 antibody
    • MGC10966 antibody
    • MIG 2 antibody
    • MIG2 like protein antibody
    • MIG2-like protein antibody
    • MIG2B antibody
    • Unc 112 related protein 2 antibody
    • Unc-112-related protein 2 antibody
    • UNC112C antibody
    • URP2_HUMAN antibody
    • URP2SF antibody
    see all

Anti-URP2 antibody 画像

  • Anti-URP2 antibody (ab106741) at 1 µg/ml + Human Peripheral Blood Mononucleocytes lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 76 kDa

Anti-URP2 antibody (ab106741) 使用論文

ab106741 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106741.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"