製品の概要

  • 製品名Anti-Uromucoid antibody
    Uromucoid 一次抗体 製品一覧
  • 製品の詳細
    Sheep polyclonal to Uromucoid
  • アプリケーション適用あり: ELISA, IHC-Frmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Human Uromucoid, purified from urine

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% EACA, 0.01% Benzamidine, Glycine buffered saline, 1mM EDTA, pH 7.4
  • Concentration information loading...
  • 精製度Ammonium Sulphate Precipitation
  • 特記事項(精製)Ig fraction prepared by ammonium sulphate fractionation.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab53588 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/10000 - 1/40000.
IHC-Fr 1/50 - 1/200.

ターゲット情報

  • 機能Not known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
  • 組織特異性Synthesized by kidney. Most abundant protein in normal human urine.
  • 関連疾患Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
    Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
    Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
  • 配列類似性Contains 3 EGF-like domains.
    Contains 1 ZP domain.
  • 細胞内局在Cell membrane. Secreted. Secreted after cleavage in the urine.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADMCKD2 antibody
    • FJHN antibody
    • HNFJ antibody
    • HNFJ1 antibody
    • MCKD2 antibody
    • medullary cystic kidney disease 2 (autosomal dominant) antibody
    • Tamm Horsfall glycoprotein antibody
    • Tamm Horsfall urinary glycoprotein antibody
    • Tamm-Horsfall urinary glycoprotein antibody
    • THGP antibody
    • THP antibody
    • Umod antibody
    • Urehd1 antibody
    • urehr4 antibody
    • UROM_HUMAN antibody
    • uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody
    • Uromodulin antibody
    • Uromodulin, secreted form antibody
    see all

Anti-Uromucoid antibody (ab53588) 使用論文

ab53588 has not yet been referenced specifically in any publications.

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Thank you for contacting us. This product is partially purified by ammonium sulfate precipitation. Due to the nature of this purification, an exact concentration can not be determined. However, an estimate of specific antibody present in this prepa...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"