製品の概要

  • 製品名
    URB754
  • 製品の詳細
    Monoacylglycerol lipase inhibitor
  • 生理活性の詳細
    Reported potent and non-competitive monoacylglycerol lipase (MAGL) inhibitor (IC50 = 200 nM). Inhibits FAAH (IC50 = 32 µM) and binds weakly to the rat CB1 receptor (IC50 = 3.8 µM). Shows vasodilatory activity.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Hillard CJ  et al. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. Br J Pharmacol 152:691-8 (2007). Read more (PubMed: 17891162) »
  • Saario SM  et al. URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. Chem Biol 13:811-4 (2006). Read more (PubMed: 16931330) »
  • Makara JK  et al. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci 8:1139-41 (2005). Read more (PubMed: 16116451) »

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