製品の概要

  • 製品名Anti-UNG antibody
    UNG 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to UNG
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length human UNG protein (NP_003353.1).

  • ポジティブ・コントロール
    • Human placenta tissue lysate. Cell lysate from transfected 293T cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 1 x PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab89640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa.
ICC/IF Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
  • 組織特異性Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
  • 関連疾患Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 syndrome (HIGM5) [MIM:608106]. Hyper-IgM syndrome is a condition characterized by normal or increased serum IgM concentrations associated with low or absent serum IgG, IgA, and IgE concentrations. HIGM5 is associated with profound impairment in immunoglobulin (Ig) class-switch recombination (CSR) at a DNA precleavage step.
  • 配列類似性Belongs to the uracil-DNA glycosylase family.
  • 翻訳後修飾Isoform 1 is processed by cleavage of a transit peptide.
  • 細胞内局在Mitochondrion and Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DGU antibody
    • DKFZp781L1143 antibody
    • HIGM 4 antibody
    • HIGM4 antibody
    • OTTHUMP00000240527 antibody
    • OTTHUMP00000240528 antibody
    • OTTHUMP00000240529 antibody
    • UDG antibody
    • UNG 1 antibody
    • UNG 15 antibody
    • ung antibody
    • UNG_HUMAN antibody
    • UNG1 antibody
    • UNG15 antibody
    • UNG2 antibody
    • Uracil DNA glycosylase 1 antibody
    • Uracil DNA glycosylase 2 antibody
    • Uracil DNA glycosylase antibody
    • Uracil-DNA glycosylase antibody
    see all

Anti-UNG antibody 画像

  • Anti-UNG antibody (ab89640) at 1 µg/ml + human placenta tissue lysate at 50 µg
    Developed using the ECL technique

    Predicted band size : 35 kDa
    Observed band size : ~30 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-UNG antibody (ab89640) at 1 µg/ml

    Lane 1 : cell lysate from UNG transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.

    Developed using the ECL technique

    Predicted band size : 35 kDa
    Observed band size : 35 kDa
    Additional bands at : ~30 kDa. We are unsure as to the identity of these extra bands.
  • ab89640 at 10 µg/ml staining UNG in paraformaldehyde fixed, permeabilised HeLa cells by immunofluorescence.

Anti-UNG antibody (ab89640) 使用論文

ab89640 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"