製品の概要

  • 製品名Anti-UNC5C antibody
    UNC5C 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to UNC5C
  • アプリケーション適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Chicken, Dog
  • 免疫原

    Synthetic peptide:

    NCTVSEEPTGID

    , corresponding to internal sequence amino acids 812-823 of Human UNC5C (NP_003719.3)

  • ポジティブ・コントロール
    • Mouse pancreat islet cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 50 µg/ml.
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
  • 組織特異性Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.
  • 配列類似性Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • 翻訳後修飾Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • homolog of C. elegans transmembrane receptor Unc5 antibody
    • Netrin receptor UNC5C antibody
    • Protein unc 5 homolog C antibody
    • Protein unc-5 homolog 3 antibody
    • Protein unc-5 homolog C antibody
    • Unc 5 homolog 3 antibody
    • Unc 5 homolog C antibody
    • Unc5 (C.elegans homolog) c antibody
    • Unc5c antibody
    • UNC5C_HUMAN antibody
    • UNC5H3 antibody
    see all

Anti-UNC5C antibody 画像

  • Staining of paraffin embedded Mouse pancreas endocrine islets (red) using ab106949 at 50 µg/ml. Nuclear staining in blue and ductal cell staining in green.
  • ab106949 (3.8µg/ml) staining of paraffin embedded Human Cerebral Cortex shows staining of some neuronal bodies plus intense axonal staining. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-UNC5C antibody (ab106949) 使用論文

ab106949 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106949.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"