製品の概要

  • 製品名Anti-UNC5B antibody
    UNC5B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to UNC5B
  • アプリケーション適用あり: WB, ELISA, ICC/IF, IHC-FoFrmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse
  • 免疫原

    UNC5B Human recombinant protein.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab104871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/5000. Predicted molecular weight: 104 kDa.
ELISA Use at an assay dependent concentration.
ICC/IF 1/100 - 1/500.
IHC-FoFr Use at an assay dependent concentration. PubMed: 23232257

ターゲット情報

  • 機能Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • 組織特異性Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
  • 配列類似性Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • 翻訳後修飾Phosphorylated on cytoplasmic tyrosine residues.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
    Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • 細胞内局在Cell membrane. Membrane raft. Associated with lipid rafts.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 6330415E02Rik antibody
    • A630020F16 antibody
    • D10Bwg0792e antibody
    • Netrin receptor UNC5B antibody
    • Netrin receptor UNC5B Precursor antibody
    • p53 regulated receptor for death and life antibody
    • p53 regulated receptor for death and life protein 1 antibody
    • p53-regulated receptor for death and life protein 1 antibody
    • p53RDL1 antibody
    • Protein unc-5 homolog 2 antibody
    • Protein unc-5 homolog B antibody
    • Protein XUNC 5 antibody
    • Transmembrane receptor Unc5H2 antibody
    • Unc 5 homolog 2 antibody
    • Unc 5 homolog B antibody
    • Unc 5 netrin receptor B antibody
    • UNC 5B antibody
    • Unc5 (C.elegans homolog) b antibody
    • Unc5b antibody
    • UNC5B_HUMAN antibody
    • UNC5H2 antibody
    see all

Anti-UNC5B antibody 画像

  • Immunohistochemical analysis of paraformaldehyde-perfusion fixed Rat brain tissue, staining UNC5B (red) with ab104871 at 1/300 dilution.

     

Anti-UNC5B antibody (ab104871) 使用論文

This product has been referenced in:
  • Liao SJ  et al. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. Neuroscience 231:225-32 (2013). IHC-FoFr ; Rat . Read more (PubMed: 23232257) »
  • Westenskow PD  et al. Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting. J Clin Invest N/A:N/A (2013). IHC ; Mouse . Read more (PubMed: 24084735) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"