Anti-UNC13B 抗体 (ab97924)
Key features and details
- Rabbit polyclonal to UNC13B
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-UNC13B antibody
UNC13B 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to UNC13B -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Zebrafish -
免疫原
Recombinant protein fragment corresponding to a region within amino acids 680 and 927 of Human UNC13B (NP_006368)
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ポジティブ・コントロール
- 293T, H1299, HeLa or HepG2 cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab97924の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 181 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 181 kDa. |
ターゲット情報
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機能
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. -
組織特異性
Expressed in kidney cortical epithelial cells and brain. -
配列類似性
Belongs to the unc-13 family.
Contains 3 C2 domains.
Contains 1 MHD1 (MUNC13 homology domain 1) domain.
Contains 1 MHD2 (MUNC13 homology domain 2) domain.
Contains 1 phorbol-ester/DAG-type zinc finger. -
ドメイン
The C2 domains are not involved in calcium-dependent phospholipid binding. -
細胞内局在
Cytoplasm. Membrane. Cell membrane. Cell junction > synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding. - Information by UniProt
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参照データベース
- Entrez Gene: 10497 Human
- Entrez Gene: 22249 Mouse
- Entrez Gene: 64830 Rat
- Omim: 605836 Human
- SwissProt: O14795 Human
- SwissProt: Q9Z1N9 Mouse
- SwissProt: Q62769 Rat
- Unigene: 493791 Human
see all -
別名
- hmunc13 antibody
- MGC133279 antibody
- MGC133280 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab97924 は 3 報の論文で使用されています。
- Brown AL et al. TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. Nature 603:131-137 (2022). PubMed: 35197628
- Oguchi ME et al. A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis. J Biol Chem 295:12674-12685 (2020). PubMed: 32669361
- Xu R et al. Munc13-4 mediates human neutrophil elastase-induced airway mucin5AC hypersecretion by interacting with syntaxin2. Mol Med Rep 18:1015-1024 (2018). PubMed: 29767240