Anti-ULBP2 抗体 [MM0593-7F33] (ab89930)
Key features and details
- Mouse monoclonal [MM0593-7F33] to ULBP2
- Suitable for: Flow Cyt, Neutralising
- Reacts with: Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-ULBP2 antibody [MM0593-7F33]
ULBP2 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MM0593-7F33] to ULBP2 -
由来種
Mouse -
アプリケーション
適用あり: Flow Cyt, Neutralisingmore details -
種交差性
交差種: Human -
免疫原
Recombinant Human ULBP2 protein
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter. -
ポリ/モノ
モノクローナル -
クローン名
MM0593-7F33 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab89930の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
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Neutralising |
Use at an assay dependent concentration.
|
特記事項 |
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Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Neutralising
Use at an assay dependent concentration. |
ターゲット情報
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機能
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. -
組織特異性
Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. -
配列類似性
Belongs to the MHC class I family. -
細胞内局在
Cell membrane. Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 80328 Human
- Omim: 605698 Human
- SwissProt: Q9BZM5 Human
- Unigene: 656778 Human
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別名
- ALCAN alpha antibody
- ALCAN-alpha antibody
- N2DL 2 antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (3)
ab89930 は 3 報の論文で使用されています。
- Chitadze G et al. In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment. Oncoimmunology 6:e1358839 (2017). PubMed: 29147621
- Chitadze G et al. NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human ?d T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors. Oncoimmunology 5:e1093276 (2016). Flow Cyt . PubMed: 27141377
- Fernández L et al. In vitro Natural Killer Cell Immunotherapy for Medulloblastoma. Front Oncol 3:94 (2013). Flow Cyt ; Human . PubMed: 23626949