製品の概要

  • 製品名Anti-ULBP1 antibody [MM0592-10K10]
    ULBP1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0592-10K10] to ULBP1
  • アプリケーション適用あり: Neutralising, Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length Human protein.

  • 特記事項


    Suitable for neutralization of ligand-receptor interaction.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 一次抗体 備考Suitable for neutralization of ligand-receptor interaction.
  • ポリ/モノモノクローナル
  • クローン名MM0592-10K10
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab89929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Neutralising Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/100. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • 組織特異性Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • 配列類似性Belongs to the MHC class I family.
  • 細胞内局在Cell membrane. Endoplasmic reticulum. Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alcan beta antibody
    • ALCAN-beta antibody
    • N2DL-1 antibody
    • N2DL1 antibody
    • N2DL1_HUMAN antibody
    • NKG2D ligand 1 antibody
    • NKG2D ligand 1 precursor antibody
    • NKG2DL1 antibody
    • RAET1I antibody
    • Retinoic acid early transcript 1I antibody
    • UL16 antibody
    • UL16 binding protein 1 antibody
    • UL16-binding protein 1 antibody
    • ULBP1 antibody
    see all

Anti-ULBP1 antibody [MM0592-10K10] (ab89929) 使用論文

ab89929 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"