製品の概要

  • 製品名Anti-ULBP1 antibody
    ULBP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ULBP1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee
  • 免疫原

    Synthetic peptide, corresponding to a region within N terminal amino acids 2-51 (AAAASPAFLL CLPLLHLLSG WSRAGWVDTH CLCYDFIITP KSRPEPQWCE) of Human ULBP1 (NP_079494)

  • ポジティブ・コントロール
    • PANC1 cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab90039 is purified by a peptide affinity chromatography method.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab90039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • 組織特異性Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • 配列類似性Belongs to the MHC class I family.
  • 細胞内局在Cell membrane. Endoplasmic reticulum. Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alcan beta antibody
    • ALCAN-beta antibody
    • N2DL-1 antibody
    • N2DL1 antibody
    • N2DL1_HUMAN antibody
    • NKG2D ligand 1 antibody
    • NKG2D ligand 1 precursor antibody
    • NKG2DL1 antibody
    • RAET1I antibody
    • Retinoic acid early transcript 1I antibody
    • UL16 antibody
    • UL16 binding protein 1 antibody
    • UL16-binding protein 1 antibody
    • ULBP1 antibody
    see all

Anti-ULBP1 antibody 画像

  • Anti-ULBP1 antibody (ab90039) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 28 kDa
    Observed band size : 28 kDa

Anti-ULBP1 antibody (ab90039) 使用論文

ab90039 has not yet been referenced specifically in any publications.

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