製品の概要

  • 製品名Anti-UHRF1 antibody
    UHRF1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to UHRF1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 275-325 of Human UHRF1 (NP_001041666.1)

  • ポジティブ・コントロール
    • Human Bladder Cell Carcinoma, Human Breast Carcinoma, Human Skin Basal Cell Carcinoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab100810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500.

ターゲット情報

  • 機能Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
  • 組織特異性Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Contains 1 PHD-type zinc finger.
    Contains 2 RING-type zinc fingers.
    Contains 1 ubiquitin-like domain.
    Contains 1 YDG domain.
  • 発生段階Expressed in fetal thymus, liver and kidney.
  • ドメインThe RING finger is required for ubiquitin ligase activity.
    The YDG domain mediates the interaction with histone H3.
  • 翻訳後修飾Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.
    Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Ac2-121 antibody
    • AL022808 antibody
    • E3 ubiquitin-protein ligase UHRF1 antibody
    • EC 6.3.2.- antibody
    • FLJ21925 antibody
    • hNP95 antibody
    • hUHRF1 antibody
    • HuNp95 antibody
    • ICBP90 antibody
    • Inverted CCAAT box binding protein of 90 kDa antibody
    • Inverted CCAAT box binding protein, 90-kD antibody
    • Inverted CCAAT box-binding protein of 90 kDa antibody
    • Liver regeneration-related protein LRRG126 antibody
    • MGC138707 antibody
    • NP95 antibody
    • Nuclear phosphoprotein, 95-KD antibody
    • Nuclear protein 95 antibody
    • Nuclear zinc finger protein Np95 antibody
    • RING finger protein 106 antibody
    • RNF106 antibody
    • Transcription factor ICBP90 antibody
    • Ubiquitin like containing PHD and RING finger domains protein 1 antibody
    • Ubiquitin like PHD and RING finger domain containing protein 1 antibody
    • Ubiquitin-like PHD and RING finger domain-containing protein 1 antibody
    • Ubiquitin-like protein containing PHD and RING finger domains 1 antibody
    • Ubiquitin-like with PHD and ring finger domains 1 antibody
    • Ubiquitin-like, containing PHD and RING finger domains, 1 antibody
    • Ubiquitin-like-containing PHD and RING finger domains protein 1 antibody
    • UHRF1 antibody
    • UHRF1_HUMAN antibody
    see all

Anti-UHRF1 antibody 画像

  • Staining of Human UHRF1 in a Formalin/PFA-fixed paraffin-embedded section of Human Basal Cell Carcinoma using ab100810 at a dilution of 1/250.
  • Staining of Human UHRF1 in a Formalin/PFA-fixed paraffin-embedded section of Human Breast Carcinoma using ab100810 at a dilution of 1/250.

Anti-UHRF1 antibody (ab100810) 使用論文

ab100810 has not yet been referenced specifically in any publications.

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Thank you for contacting us.

In general, as negative control the following could be used:

-a tissue that does not express the protein (see HumanProtein Atlas- spleen tissue:
http://www.proteinatlas.org/ENSG00000034063/normal,...

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Thank you for contacting us with your enquiry.

Ab27478 is a suitable isotype control to use with an unconjugated rabbit polyclonal primary antibody, so I would recommend using it as a negative controlfor ab100810 and ab7046 in IHC. As the IgG...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"