製品の概要

  • 製品名Anti-UGT1A4 antibody
    UGT1A4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to UGT1A4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 59-108 (VVLTPEVNMH IKEEKFFTLT AYAVPWTQKE FDRVTLGYTQ GFFETEHLLK) of Human UGT1A4 (NP_009051).

  • ポジティブ・コントロール
    • HepG2 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab105781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.
  • 組織特異性Expressed in liver. Not expressed in skin or kidney.
  • 関連疾患Defects in UGT1A4 are the cause of Gilbert syndrome (GILBS) [MIM:143500]. Gilbert syndrome occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague nonspecific complaints.
    Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 1 (CN1) [MIM:218800]. CN1 patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive.
    Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 2 (CN2) [MIM:606785]. CN2 patients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant.
  • 配列類似性Belongs to the UDP-glycosyltransferase family.
  • 細胞内局在Microsome. Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Bilirubin UDP glucuronosyltransferase isozyme 2 antibody
    • Bilirubin-specific UDPGT isozyme 2 antibody
    • HUG-BR2 antibody
    • UD14_HUMAN antibody
    • UDP glucuronosyltransferase 1 family polypeptide A4 antibody
    • UDP glycosyltransferase 1 family polypeptide A4 antibody
    • UDP-glucuronosyltransferase 1-4 antibody
    • UDP-glucuronosyltransferase 1-D antibody
    • UDP-glucuronosyltransferase 1A4 antibody
    • UDPGT 1-4 antibody
    • UDPGT antibody
    • UGT-1D antibody
    • UGT1*4 antibody
    • UGT1-04 antibody
    • UGT1.4 antibody
    • UGT1A4 antibody
    • UGT1D antibody
    see all

Anti-UGT1A4 antibody 画像

  • Anti-UGT1A4 antibody (ab105781) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 60 kDa

Anti-UGT1A4 antibody (ab105781) 使用論文

ab105781 has not yet been referenced specifically in any publications.

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