製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to UFD1L
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Recombinant fragment
    交差が予測される動物種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to C terminal residues of UFD1L (Human)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.

ターゲット情報

  • 機能
    Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
  • 組織特異性
    Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
  • パスウェイ
    Protein degradation; proteasomal ubiquitin-dependent pathway.
  • 配列類似性
    Belongs to the UFD1 family.
  • 細胞内局在
    Nucleus. Cytoplasm > cytosol.
  • Information by UniProt
  • 参照データベース
  • 別名
    • UB fusion protein 1 antibody
    • Ubiquitin fusion degradation 1 like (yeast) antibody
    • Ubiquitin fusion degradation 1 like antibody
    • Ubiquitin fusion degradation protein 1 homolog antibody
    • UFD1 antibody
    • UFD1_HUMAN antibody
    • UFD1L antibody
    see all

プロトコール

参考文献

ab56208 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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