製品の概要

  • 製品名Anti-UEV1A antibody
    UEV1A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to UEV1A
  • 特異性This antibody may also recognize isoform b of UEV1.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Xenopus laevis, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide:

    TFTNQIHKWSHTYFGLPRW

    , corresponding to amino acids 31-49 of Human UEV1 (170 aa isoform a).

  • ポジティブ・コントロール
    • Jurkat cell lysates. HeLa cell lysates. RAW (mouse) cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab46949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 20 kDa in Jurkat, RAW and HeLa cell lysates.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation.
    • 細胞内局在Nuclear
    • 参照データベース
    • 別名
      • CIR1 antibody
      • CROC1 antibody
      • CROC1A antibody
      • DNA binding protein antibody
      • P/OKcl.19 antibody
      • TRAF6-regulated IKK activator 1 beta Uev1A antibody
      • UBE2V antibody
      • UBE2V1 antibody
      • Ubiquitin-conjugating enzyme E2 variant 1 antibody
      • UEV 1A antibody
      • UEV-1 antibody
      • UEV1 antibody
      • UEV1A antibody
      see all

    Anti-UEV1A antibody 画像

    • Anti-UEV1A antibody (ab46949) at 1 µg/ml + Jurkat cell lysate

      Observed band size : 20 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 97 kDa. We are unsure as to the identity of these extra bands.

    Anti-UEV1A antibody (ab46949) 使用論文

    ab46949 has not yet been referenced specifically in any publications.

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