製品の概要

  • 製品名Anti-UBR1 antibody
    UBR1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to UBR1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: ADEEAGGTER MEISAELPQT PQRLASWWDQ QVDFYTAFLH HLAQLVPEIY FAEMDPDLEK QEESVQMSIF TPLEWYLFGE DPDICLEKLK HSGAFQLCG, corresponding to amino acids 2-101 of Human UBR1

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG1
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab58117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
    • 組織特異性Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
    • パスウェイProtein modification; protein ubiquitination.
    • 関連疾患Defects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS) [MIM:243800]. This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis.
    • 配列類似性Belongs to the UBR1 family.
      Contains 1 RING-type zinc finger.
      Contains 1 UBR-type zinc finger.
    • 発生段階Expressed in fetal pancreas.
    • ドメインThe RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Cytoplasm > cytosol.
    • Information by UniProt
    • 参照データベース
    • 別名
      • E3 ubiquitin-protein ligase UBR1 antibody
      • JBS antibody
      • N-recognin-1 antibody
      • ubiquitin protein ligase E3 component n-recognin 1 antibody
      • Ubiquitin-protein ligase E3-alpha-1 antibody
      • Ubiquitin-protein ligase E3-alpha-I antibody
      • UBR1 antibody
      • UBR1_HUMAN antibody
      see all

    Anti-UBR1 antibody 画像



    • Predicted band size : 200 kDa
      UBR1 antibody (ab58117) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-UBR1 antibody (ab58117) 使用論文

    ab58117 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58117.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"