製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to UBASH3A
  • 特異性
    ab59122 is expected to recognize both reported isoforms (NP_061834.1 and NP_001001895.1).
  • アプリケーション
    適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Dog
  • 免疫原

    Synthetic peptide:

    QQCSTPDGKYYRPD

    , corresponding to internal sequence amino acids 417-430 of Human UBASH3A

  • ポジティブ・コントロール
    • Daudi cell lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab59122 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/64000.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
  • 組織特異性
    Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
  • 配列類似性
    Contains 1 SH3 domain.
    Contains 1 UBA domain.
  • 細胞内局在
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cbl interacting protein 4 antibody
    • Cbl-interacting protein 4 antibody
    • CLIP4 antibody
    • STS 2 antibody
    • STS-2 antibody
    • Suppressor of T cell receptor signaling 2 antibody
    • Suppressor of T-cell receptor signaling 2 antibody
    • T cell ubiquitin ligand antibody
    • T cell ubiquitin ligand protein antibody
    • T-cell ubiquitin ligand 1 antibody
    • TULA antibody
    • TULA-1 antibody
    • UBASH3A antibody
    • ubiquitin associated and SH3 domain containing, A antibody
    • Ubiquitin-associated and SH3 domain-containing protein A antibody
    • UBS3A_HUMAN antibody
    see all

画像

  • ab59122 (2.5 µg/ml) staining UBASH3A in human spleen by IHC-P.  Steamed antigen retrieval with citrate buffer pH 6, AP-staining.  The image shows cytoplasm staining of T-cells eccentrically gathered around an artery.

プロトコール

参考文献

ab59122 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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