製品の概要

  • 製品名Anti-UACA antibody
    UACA 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to UACA
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Rabbit, Cow, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within residue 1075-1125 (LSQKYTEVKN VKEKLVEENA KQTSEILAVQ NLLQKQHVPL EQVEALKKSL N) of Human UACA (NP_060473.2).

  • ポジティブ・コントロール
    • HeLa and 293T whole cell lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99323 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000 - 1/10000. Predicted molecular weight: 162 kDa.
IP Use at 2-5 µg/mg of lysate.

ターゲット情報

  • 機能Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
    Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury.
  • 組織特異性Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
  • 配列類似性Contains 6 ANK repeats.
  • 細胞内局在Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Expressed diffusely in cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ10128 antibody
    • KIAA1561 antibody
    • MGC141967 antibody
    • MGC141969 antibody
    • Nuclear membrane binding protein antibody
    • NUCLING antibody
    • UACA antibody
    • UACA_HUMAN antibody
    • Uveal autoantigen with coiled coil domains and ankyrin repeats antibody
    • Uveal autoantigen with coiled-coil domains and ankyrin repeats antibody
    see all

Anti-UACA antibody 画像

  • All lanes : Anti-UACA antibody (ab99323) at 0.04 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : HeLa whole cell lysate at 5 µg
    Lane 4 : 293T whole cell lysate at 50 µg

    Developed using the ECL technique

    Predicted band size : 162 kDa


    Exposure time : 10 seconds
  • Detection of UACA in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded), using ab99323 at 3 µg/mg lysate for IP (Lane 1) and at 1 µg/ml for subsequent Western blot detection. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 3 seconds.

Anti-UACA antibody (ab99323) 使用論文

ab99323 has not yet been referenced specifically in any publications.

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