生理活性の詳細GABAA antagonist that interacts with the picrotoxin site and stabilizes the GABAA receptor/Cl- channel complex in an inactivated state. Causes rapid decay of gamma-aminobutyric acid-induced chloride currents.
保存方法Store at Room Temperature. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Bell-Horner CL et al. Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABA(A) receptors. Brain Res Mol Brain Res76:47-55 (2000).
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Dillon GH et al. [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J Pharmacol Exp Ther272:597-603 (1995).
Read more (PubMed: 7531762) »
Dillon GH et al. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors. Mol Pharmacol44:860-5 (1993).
Read more (PubMed: 8232235) »