製品の概要

  • 製品名
    U-51605
  • 製品の詳細
    Selective PGI2 and TXA2 synthase inhibitor. PGH2 analog.
  • 生理活性の詳細
    Selective inhibitor of PGI2 synthase (IC50 = 2 μM) and TXA2 synthase. PGH2 analog. Partial agonist at TP receptors.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Li YC  et al. Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change. J Biol Chem 283:2917-26 (2008). Read more (PubMed: 18032380) »
  • Gluais P  et al. In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. Am J Physiol Heart Circ Physiol 291:H2255-64 (2006). Read more (PubMed: 16798820) »
  • Zou M  et al. Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. Br J Pharmacol 126:1283-92 (1999). Read more (PubMed: 10217520) »
  • Mukhopadhyay A  et al. Effect of trimetoquinol analogs for antagonism of endoperoxide/thromboxane A2-mediated responses in human platelets and rat aorta. J Pharmacol Exp Ther 232:1-9 (1985). Read more (PubMed: 3855323) »

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