Anti-Tyrosine Hydroxylase (phospho S40) 抗体 (ab51206)


  • 製品名
    Anti-Tyrosine Hydroxylase (phospho S40) antibody
    Tyrosine Hydroxylase 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Tyrosine Hydroxylase (phospho S40)
  • 特異性
    ab51206 detects endogenous levels of Tyrosine.
  • アプリケーション
    適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Goat, Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthesized phosphopeptide derived from human Tyrosine Hydroxylase around the phosphorylation site of serine 40 (R-Q-SP-L-I).

  • ポジティブ・コントロール
    • Human brain tissue; extracts from RAW264.7 cells.



Our Abpromise guarantee covers the use of ab51206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/300 - 1/1000. Detects a band of approximately 59 kDa (predicted molecular weight: 59 kDa).
ELISA 1/40000.
IHC-P Use at an assay dependent concentration.


  • 機能
    Plays an important role in the physiology of adrenergic neurons.
  • 組織特異性
    Mainly expressed in the brain and adrenal glands.
  • パスウェイ
    Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • 関連疾患
    Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • 配列類似性
    Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Dystonia 14 antibody
    • DYT14 antibody
    • DYT5b antibody
    • EC antibody
    • OTTHUMP00000011225 antibody
    • OTTHUMP00000011226 antibody
    • ple antibody
    • Protein Pale antibody
    • TH antibody
    • The antibody
    • TY3H_HUMAN antibody
    • TYH antibody
    • Tyrosine 3 hydroxylase antibody
    • Tyrosine 3 monooxygenase antibody
    • Tyrosine 3-hydroxylase antibody
    • Tyrosine 3-monooxygenase antibody
    • Tyrosine hydroxylase antibody
    see all

Anti-Tyrosine Hydroxylase (phospho S40) antibody 画像

  • This image shows human brain tissue stained with ab51206 at a dilution of 1/50-1/100. Right hand image: treated with immunising peptide; left hand image: untreated.
  • All lanes : Anti-Tyrosine Hydroxylase (phospho S40) antibody (ab51206)

    Lane 1 : Extracts from RAW264.7 cells treated with UV (30min) with immunising peptide
    Lane 2 : Extracts from RAW264.7 cells treated with UV (30min) with no immunising peptide

    Predicted band size : 59 kDa

Anti-Tyrosine Hydroxylase (phospho S40) antibody (ab51206) 使用論文

This product has been referenced in:
  • Calipari ES  et al. Dopaminergic dynamics underlying sex-specific cocaine reward. Nat Commun 8:13877 (2017). WB ; Mouse . Read more (PubMed: 28072417) »
  • Beccano-Kelly DA  et al. LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory. Hum Mol Genet 24:1336-49 (2015). Read more (PubMed: 25343991) »

See all 3 Publications for this product

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