Anti-Tyrosine Hydroxylase 抗体 (ab106806)

製品の概要

  • 製品名Anti-Tyrosine Hydroxylase antibody
    Tyrosine Hydroxylase 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Tyrosine Hydroxylase
  • 特異性This antibody is expected to recognise all three reported isoforms (as represented by NP_954986.2; NP_000351.2; NP_954987.2).
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Dog, Pig
  • 免疫原

    Synthetic peptide:

    VQDELDTLAHAL

    , corresponding to C terminal amino acids 513-524 of Human Tyrosine Hydroxylase (NP_954986.2; NP_000351.2; NP_954987.2).

  • ポジティブ・コントロール
    • Human Brain (Cerebral Cortex) lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 - 4 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 59 kDa).
IHC-Fr Use a concentration of 0.1 - 0.3 µg/ml.

ターゲット情報

  • 機能Plays an important role in the physiology of adrenergic neurons.
  • 組織特異性Mainly expressed in the brain and adrenal glands.
  • パスウェイCatecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • 関連疾患Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • 配列類似性Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Dystonia 14 antibody
    • DYT14 antibody
    • DYT5b antibody
    • EC 1.14.16.2 antibody
    • OTTHUMP00000011225 antibody
    • OTTHUMP00000011226 antibody
    • ple antibody
    • Protein Pale antibody
    • TH antibody
    • The antibody
    • TY3H_HUMAN antibody
    • TYH antibody
    • Tyrosine 3 hydroxylase antibody
    • Tyrosine 3 monooxygenase antibody
    • Tyrosine 3-hydroxylase antibody
    • Tyrosine 3-monooxygenase antibody
    • Tyrosine hydroxylase antibody
    see all

Anti-Tyrosine Hydroxylase antibody 画像



  • Predicted band size : 59 kDa
  • Anti-Tyrosine Hydroxylase antibody (ab106806) at 2 µg/ml + Human Cerebral Cortex lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 59 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)
  • ab106806 staining Tyrosine Hydroxylase in the following tissues, human hypothalamic supraoptic (SO), paraventricular (Pa) and periventricular (Pe) nuclei. Antigen retrieval with citrate buffer pH 6 at 80oC for 30 minutes.

Anti-Tyrosine Hydroxylase antibody (ab106806) 使用論文

ab106806 has not yet been referenced specifically in any publications.

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